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KMID : 0043320100330070971
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Archives of Pharmacal Research
2010 Volume.33 No. 7 p.971 ~ p.980
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Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity
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Jain Priyal
Sharma Prakash Kumar
Rajak Harish
Pawar Rajesh Singh
Patil Umesh Kumar
Singour Pradeep Kumar
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Abstract
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Selective GABAA receptor ligands are widely used clinically to reduce the occurrence of convulsions. Hence there is an intense interest in developing new benzimidazole derivatives demonstrating high selectivity and high affinity for GABAA receptors. With the purpose of designing new chemical entities with an enhanced binding affinity for GABAA/BZd receptor complex, we carried out a QSAR study on benzotriazine derivatives. We studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various tested physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features. The developed and validated final model showed a good correlative and predictive ability expressed by a squared correlation co-efficient (r2) of 0.954. The equation indicated that the binding affinity is strongly dependent upon the thermodynamic properties (CDE, DDE and PC). Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity in both the convulsion models.
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KEYWORD
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QSAR, Anticonvulsant, Benzimidazole, MES and PTZ convulsions
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